In this episode of AMCP Unscripted Podcast, Steve Kheloussi, Principal Consultant with Kheloussi Consulting, speaks with Dr. Kirollos Hanna, Director of Pharmacy at Minnesota Oncology and Assistant Professor of Pharmacy at the Mayo Clinic College of Medicine, about precision oncology in advanced breast cancer and the role of managed care. They discuss the evolving use of biomarker testing and circulating tumor DNA to identify ESR1 mutations, considerations for coverage and prior authorization, and the need to better align laboratory, medical, and pharmacy benefits as new evidence and treatment approaches emerge. This podcast is sponsored by AstraZeneca.