The Inflation Reduction Act (IRA) was signed into law on Aug. 16, 2022. Among the topics covered by the IRA are Medicare price negotiation for qualifying single-source drugs; manufacturer rebates for certain drugs paid under Medicare Parts B or D if their average prices increase faster than the rate of inflation; Part D redesign including eliminating the coverage gap, setting an annual out-of-pocket cap (initially $2,000), limits to premium increases, mandated coverage for vaccines, and a $35 monthly insulin cap. Many questions remain about the implementation of this law, which will be done through agency guidance, program instruction, agreements between CMS and drug manufacturers, and notice-and-comment rulemaking. This resource center provides resources to help answer those questions and provide additional information.